Small Molecule Inhibitors of Phosphodiesterases Discovered

Small Molecule Inhibitors of Phosphodiesterases Discovered

Mohd Ishaq Dar

34,52 €
IVA incluido
Consulta disponibilidad
Editorial:
Draft2Digital
Año de edición:
2024
Materia
Genética (no médica)
ISBN:
9798224180547
Añadir a favoritos

Phosphodiesterases (PDEs) are a group of enzymes that catalyze the hydrolysis of cyclic nucleotides, such as cAMP and cGMP, which play crucial roles in various signaling pathways in the body. Small molecule inhibitors of phosphodiesterases have been discovered as a promising strategy for the development of drugs that target these enzymes. The discovery of small molecule inhibitors of phosphodiesterases has great potential in drug development for a wide range of therapeutic applications. These inhibitors have shown promising results in the treatment of several diseases such as heart failure, pulmonary arterial hypertension, Alzheimer’s disease, Parkinson’s disease, and cancer. The inhibitors have been found to have anti-inflammatory, antiplatelet, neuroprotective, antidepressant, and cognition-enhancing properties, making them attractive for drug development. Phosphodiesterase inhibitors work by preventing the breakdown of cyclic nucleotides, resulting in increased levels of cAMP and cGMP. This, in turn, leads to smooth muscle relaxation, vasodilation, and bronchodilation. The inhibitors also modulate other signaling pathways, including cyclic AMP-dependent protein kinase and protein kinase G, leading to a broad range of therapeutic effects. The discovery of small molecule inhibitors of phosphodiesterases involves several approaches such as virtual screening, molecular docking, structure-based drug design, ligand-based drug design, and high-throughput screening. The process also includes lead optimization, pharmacophore modeling, drug binding, binding affinity, and structure-activity relationships (SAR) analysis. Furthermore, the inhibitors’ pharmacokinetics, pharmacodynamics, ADME, toxicity, and drug delivery aspects are also evaluated during the drug development process. Preclinical studies and clinical trials are conducted to assess the efficacy and safety of these inhibitors. The results of these studies have demonstrated the therapeutic potential of these inhibitors in various diseases.In summary, the discovery of small molecule inhibitors of phosphodiesterases has opened up new avenues for drug development in several therapeutic areas. The inhibitors have shown great promise in the treatment of various diseases and have a broad range of therapeutic effects. The drug development process involves several approaches, including virtual screening, molecular docking, and structure-based drug design. The safety and efficacy of these inhibitors are evaluated in preclinical studies and clinical trials to assess their potential for therapeutic use.

Artículos relacionados

  • PCR Troubleshooting and Optimization
    Suzanne Kennedy
    The polymerase chain reaction (PCR) is a fundamental tool in scientific research and clinical testing. Real-time PCR, combining both amplification and detection in one instrument, is a rapid and accurate method for nucleic acid detection and quantification. Although PCR is a very powerful technique, the results achieved are valid only if the appropriate controls have been emplo...
  • BIOCOMPUTING 2018
    A KEITH DUNKER LAWRENCE RUSS B ALTMAN
     The Pacific Symposium on Biocomputing (PSB) 2018 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2018 will be held on January ...
    Disponible

    287,37 €

  • Quantitative Real-Time PCR in Applied Microbiology
    Filion
    Real time quantitative PCR (qPCR) technology has revolutionized almost all areas of microbiology, including clinical microbiology, food microbiology, industrial microbiology, environmental microbiology, and microbial biotechnology. Various modifications and improvements have enhanced the overall performance of this highly versatile technology and the qPCR instrumentation and st...
  • BIOCOMPUTING 2016 - PROCEEDINGS OF THE PACIFIC SYMPOSIUM
    A KEITH DUNKER LAWRENCE RUSS B ALTMAN
     The Pacific Symposium on Biocomputing (PSB) 2016 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2016 will be held on January ...
    Disponible

    267,56 €

  • Tratamento Avançado para Síndrome de Marfan
    Josias Monias Xavier
    A Síndrome de Marfan é uma condição complexa que desafia a compreensão convencional da medicina. Neste livro, o autor nos leva a uma jornada fascinante pelo mundo da Apometria, Programação Neurolinguística (PNL), Regressão e Hipnose, explorando abordagens alternativas e holísticas para o tratamento desta síndrome e outras condições genéticas. É uma obra que desafia os limites d...
  • The DNA Manifesto
    V T HARIKUMAR
    In 'The DNA Manifesto: Charting the Course of the Genetic Revolution,' author HARIKUMAR V T takes readers on a captivating journey through the rapidly evolving landscape of genetics and its profound implications for humanity. With clarity and insight, the book navigates through the complexities of DNA science, offering a compelling narrative that explores both the promises and ...